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KMID : 0366219710060010027
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Korean Journal of Hematology
1971 Volume.6 No. 1 p.27 ~ p.36
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Studies with Co57-Vitamin B12 on Metabolism of Vitamin B12 in Liver Diseases
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문영명(文英明)/Young Myoung Moon
이해언(李海宣)/한지숙(韓芝淑)/이주형(李柱衡)/채응석(蔡應錫)/Hae Sun Lee/Jee Sook Hahn/Choo Hyung Lee/Eung Suk Chai
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Abstract
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In 1955 Jerzy Glass et al. reported the pattern of uptake of vitamin B12
in liver, spleen and bone marrow using Co60-vitamin B12. In
1958 they observed that the uptake of vitamin B12 in liver was lower in
patients with liver diseases than in normal persons. Stein et al. confirmed the decreased
uptake in animal experiment.
The purpose of this study was to estimate the degree of the uptake of the vitamin
B12 in the liver in normal subjects and in patients with liver diseases.
One μCi. of Co57-vitamin B12 was ingested to normal
subjects and patients with liver cirrhosis and with acute hepatitis, and checked serum
activity, stool count and surface counts on liver, spleen and iliac crest.
The following results were obtained:
1. Serum counts were highest at 8 hours after ingestion of 1μCi. of
Co57-vitamin B12 orally, but there was no difference
between in normal subjects and in patients with liver diseases.
2. The amount of Co57-vitamin B12 excreted in stool was
higher in patients with liver diseases than in normal subjects.
3. In normal subjects the surface counts on liver area reached to the peak on the 4th
day after ingestion and remained until l0th day.
4. In patients with liver diseases the surface counts on liver area were lower in
general than in normal subjects, and decreased from the 4th day and showed a
significant difference on the 10th day compared to that of normal subjects.
5. The surface counts on spleen and iliac crest were lower than on liver and were
gradually decreased in both groups.
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KEYWORD
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